Mechanism of Action

hypoglycemic agent along with metformin. Although the management of diabetes was attempted by the “experts” of the Pharaoah of Egypt 3500 years ago and by Shushruta, the modern times efforts began only in the in the early 1900. In the year 1937, hypoglycemic activity of sulfur compounds was noted, and five years later, Michel Janbon noted hypoglycemia while using antibiotic para amino sulfonamide-isopropyl-thiodiaozole. Its secretogogue action was confirmed by Loubatieres in 1946 and tolbutamide was the first SU to be marketed in Germany in 19501-2.